How does injection port liner deactivation affect peak shape in GC?

If a GC liner has active sites, analytes which contain nitrogen or oxygen atoms can interact strongly with the liner. This will cause the analytes progress into the column to be retarded, distorting the injection profile – this distortion will typically result in peaks which show appreciable tailing. In extreme cases the analytes will actually break down in the injection port, and not be present at all in the chromatogram.

When working with active compounds it is therefore important to work with liners which show a high level of deactivation.