Possible causes:
a). Sample pretreatment
Samples of different nature require different pretreatment prior to SPE. Viscous samples require a dilution. Particle-laden samples require filtering
b). Incorrect sorbent selection
A larger particle size sorbent may be more appropriate for viscous samples
c). Vacuum
Increase vacuum force to see if there is improvement. For well plates, use a sealing mat to cover unused wells.
d). Sample precipitation
Some components of your sample may precipitate and create clogging inside the cartridge
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