The reasons for noisy baseline with ELSD detectors are:
- Evaporation temperature too low - the solvent is not completely evaporated.
- Evaporation temperature too high - the solvent is boiling in the nebuliser.
- Air or nitrogen not clean - remove traces of water or oil with a gas trap.
- Gas flow too low - poor nebulisation of the eluent, increase the gas flow.
- Non-volatile material in the eluent - replace any buffer salt with a volatile one (such as ammonium acetate) and ensure that the eluent is particle free.
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